Class IV Laser Therapy – Condition Evidence

Arthritis (e.g., knee osteoarthritis)

Recent systematic reviews find that photobiomodulation (PBM)/low‑level laser therapy can reduce pain and improve short‑term function in knee osteoarthritis when appropriate dosing is used. Effects are typically small‑to‑moderate and most evident in the first weeks after treatment; parameters (wavelength, dose per point, and number of sessions) matter. 

Reference: Click here

Bone Spurs (e.g., heel spurs linked with plantar fasciitis)

Although lasers do not “dissolve” spurs, PBM has been shown to reduce heel pain and disability in plantar fasciitis— a condition commonly associated with calcaneal spurs—when clinically recommended doses are used.

Reference: Click here 

Plantar Fasciitis

Multiple randomized trials pooled in meta‑analysis report meaningful short‑term pain relief and functional gains with PBM for plantar fasciitis, particularly when dose follows published guidelines. 

Reference: Click here

Tennis & Golfer’s Elbow (lateral/medial epicondylalgia)

A classic meta‑analysis of randomized trials concluded that properly dosed PBM provides short‑term pain relief for lateral elbow tendinopathy; dosing adherence largely explains variability across trials.

Reference: Click here 

Rotator Cuff Strains and Tears / Subacromial Impingement

Randomized, double‑blind work shows that adding PBM to a shoulder exercise program can further reduce pain and improve range of motion versus exercise alone in subacromial (rotator cuff–related) pain. 

Reference: Click here

TMJ Disorder (jaw clicking and pain)

Systematic reviews and meta‑analyses of randomized trials report that PBM can reduce pain and improve mouth opening in temporomandibular disorders, though protocols vary and optimal dosing remains under study. 

Reference: Click here

Herniated Discs (lumbar radiculopathy/sciatica)

A double‑blind randomized controlled trial in patients with discogenic lumbar radiculopathy found that PBM improved pain and disability outcomes versus sham, supporting its role as a conservative adjunct. 

Reference: Click here

Tendinosis & Tendinitis (lower limb)

A recent meta‑analysis pooling plantar fasciitis and lower‑extremity tendinopathies found PBM improves patient‑reported pain and disability when delivered with evidence‑based parameters. 

Reference: Click here

Bursitis (e.g., subacromial)

Clinical trials in subacromial pain suggest PBM can add benefit to exercise‑based care for pain and function; some trials using different parameters show mixed results, highlighting the importance of correct dosing. 

Reference: Click here

Shin Splints (medial tibial stress syndrome)

Early randomized work in military recruits reported symptom improvement with PBM versus placebo; modern reviews note that evidence remains limited and newer, higher‑quality trials are needed. 

Reference: Click here 

Runner’s Knee (Patellofemoral Pain Syndrome)

Randomized studies indicate PBM can reduce anterior knee pain and improve function in PFPS, especially as part of a rehab program; emerging comparisons also explore high‑intensity protocols. 

Reference: Click here 

Carpal Tunnel Syndrome

Recent systematic reviews (including 2025 analyses) suggest PBM can reduce pain and improve hand function in mild‑to‑moderate CTS, with effects influenced by wavelength, dose, and session count. 

Reference: Click here

Ligament Tears (healing support)

Preclinical and in‑vitro studies show PBM can stimulate collagen type I synthesis and fibroblast activity in ligament tissue, biologically supporting its use alongside rehab following ligament injury or repair. 

Reference: Click here 

Sciatica

 In disc‑related radiculopathy, randomized, double‑blind trials report PBM can lessen pain and disability measures versus sham; PBM may be combined with exercise and other conservative care. 

Reference: Click here

Bunions (hallux valgus) – pain around the big toe

Direct PBM trials for bunions are scarce; however, PBM has demonstrated postoperative analgesic and anti‑inflammatory benefits in surgical populations and efficacy in several foot/ankle pain conditions, supporting its adjunctive use for bunion‑related soft‑tissue pain. 

Reference: Click here

Hip Discomfort (including post‑surgical pain)

A randomized, triple‑blind clinical trial after total hip arthroplasty found PBM reduced acute postoperative pain and inflammation versus placebo, consistent with PBM’s anti‑inflammatory effects. 

Reference: Click here

Neck, Back, and Leg Pain

A landmark Lancet meta‑analysis concluded PBM provides short‑ to medium‑term relief for neck pain; separate reviews and RCTs also support benefits in low back pain, including with higher‑intensity laser protocols. 

Reference: Click here 

Tailbone Injury (coccyx pain)

Evidence is limited, but case reports describe meaningful pain reduction in refractory coccydynia with laser‑based protocols, suggesting PBM as a low‑risk adjunct when standard care has not helped. 

Reference: Click here 

Nerve Injury, Damage & Dysfunction

Systematic reviews indicate PBM can promote peripheral nerve regeneration and functional recovery by modulating inflammation and supporting Schwann‑cell/axonal processes; dosing varies by indication. 

Reference: Click here 

Post‑Operative Healing & Recovery

Recent randomized trials in oral/implant surgery show PBM can speed soft‑tissue healing and reduce postoperative pain and swelling, aligning with its broader anti‑inflammatory and pro‑repair mechanisms. 

Reference: Click here

Notes: PBM/laser therapy should be delivered by trained clinicians using eye protection and medically appropriate parameters. Individual results vary; PBM complements (not replaces) diagnosis‑led care and rehabilitation. 

Arthritis (e.g., knee osteoarthritis)

Recent systematic reviews find that photobiomodulation (PBM)/low‑level laser therapy can reduce pain and improve short‑term function in knee osteoarthritis when appropriate dosing is used. Effects are typically small‑to‑moderate and most evident in the first weeks after treatment; parameters (wavelength, dose per point, and number of sessions) matter. 

Reference: https://academic.oup.com/ptj/article/104/8/pzae073/7679396 

Bone Spurs (e.g., heel spurs linked with plantar fasciitis)

Although lasers do not “dissolve” spurs, PBM has been shown to reduce heel pain and disability in plantar fasciitis— a condition commonly associated with calcaneal spurs—when clinically recommended doses are used.

Reference: https://bmjopen.bmj.com/content/12/9/e059479

Plantar Fasciitis

Multiple randomized trials pooled in meta‑analysis report meaningful short‑term pain relief and functional gains with PBM for plantar fasciitis, particularly when dose follows published guidelines. 

Reference: https://bmjopen.bmj.com/content/12/9/e059479

Tennis & Golfer’s Elbow (lateral/medial epicondylalgia)

A classic meta‑analysis of randomized trials concluded that properly dosed PBM provides short‑term pain relief for lateral elbow tendinopathy; dosing adherence largely explains variability across trials.

Reference: https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-9-75

Rotator Cuff Strains and Tears / Subacromial Impingement

Randomized, double‑blind work shows that adding PBM to a shoulder exercise program can further reduce pain and improve range of motion versus exercise alone in subacromial (rotator cuff–related) pain. 

Reference: https://link.springer.com/article/10.1007/s10067-011-1757-7

TMJ Disorder (jaw clicking and pain)

Systematic reviews and meta‑analyses of randomized trials report that PBM can reduce pain and improve mouth opening in temporomandibular disorders, though protocols vary and optimal dosing remains under study. 

Reference: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/2018/4230583 

Herniated Discs (lumbar radiculopathy/sciatica)

A double‑blind randomized controlled trial in patients with discogenic lumbar radiculopathy found that PBM improved pain and disability outcomes versus sham, supporting its role as a conservative adjunct. 

Reference: https://europepmc.org/article/pmc/8898844 

Tendinosis & Tendinitis (lower limb)

A recent meta‑analysis pooling plantar fasciitis and lower‑extremity tendinopathies found PBM improves patient‑reported pain and disability when delivered with evidence‑based parameters. 

Reference: https://bmjopen.bmj.com/content/12/9/e059479

Bursitis (e.g., subacromial)

Clinical trials in subacromial pain suggest PBM can add benefit to exercise‑based care for pain and function; some trials using different parameters show mixed results, highlighting the importance of correct dosing. 

Reference: https://link.springer.com/article/10.1007/s10067-011-1757-7

Shin Splints (medial tibial stress syndrome)

Early randomized work in military recruits reported symptom improvement with PBM versus placebo; modern reviews note that evidence remains limited and newer, higher‑quality trials are needed. 

Reference: https://europepmc.org/article/MED/7801390 

Runner’s Knee (Patellofemoral Pain Syndrome)

Randomized studies indicate PBM can reduce anterior knee pain and improve function in PFPS, especially as part of a rehab program; emerging comparisons also explore high‑intensity protocols. 

Reference: https://www.sciencedirect.com/science/article/pii/S1360859221000036 

Carpal Tunnel Syndrome

Recent systematic reviews (including 2025 analyses) suggest PBM can reduce pain and improve hand function in mild‑to‑moderate CTS, with effects influenced by wavelength, dose, and session count. 

Reference: https://link.springer.com/article/10.1007/s10103-024-04276-9 

Ligament Tears (healing support)

Preclinical and in‑vitro studies show PBM can stimulate collagen type I synthesis and fibroblast activity in ligament tissue, biologically supporting its use alongside rehab following ligament injury or repair. 

Reference: https://www.springermedicine.com/laser/in-vitro-study-on-type-i-collagen-synthesis-in-low-level-laser-t/27629078 

Sciatica

 In disc‑related radiculopathy, randomized, double‑blind trials report PBM can lessen pain and disability measures versus sham; PBM may be combined with exercise and other conservative care. 

Reference: https://europepmc.org/article/pmc/8898844

Bunions (hallux valgus) – pain around the big toe

Direct PBM trials for bunions are scarce; however, PBM has demonstrated postoperative analgesic and anti‑inflammatory benefits in surgical populations and efficacy in several foot/ankle pain conditions, supporting its adjunctive use for bunion‑related soft‑tissue pain. 

Reference: https://bmjopen.bmj.com/content/12/9/e059479

Hip Discomfort (including post‑surgical pain)

A randomized, triple‑blind clinical trial after total hip arthroplasty found PBM reduced acute postoperative pain and inflammation versus placebo, consistent with PBM’s anti‑inflammatory effects. 

Reference: https://link.springer.com/article/10.1007/s10103-018-2558-x 

Neck, Back, and Leg Pain

A landmark Lancet meta‑analysis concluded PBM provides short‑ to medium‑term relief for neck pain; separate reviews and RCTs also support benefits in low back pain, including with higher‑intensity laser protocols. 

Reference: https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(09)61522-1.pdf 

Tailbone Injury (coccyx pain)

Evidence is limited, but case reports describe meaningful pain reduction in refractory coccydynia with laser‑based protocols, suggesting PBM as a low‑risk adjunct when standard care has not helped. 

Reference: https://europepmc.org/article/MED/32028396 

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